| Prime Minister | Romano Prodi | (Ulivo-Ind.) |
| Deputy Prime Minister and Minister of Foreign Affairs | Massimo D’Alema | (DS) |
| Deputy Prime Minister and Minister of Culture | Francesco Rutelli | (Ulivo-M) |
| Under-Secretaries of State to the Presidency of the Council of Ministers | Enrico Letta | (Ulivo-M) |
| | Enrico Micheli | (Ulivo-Ind.) |
| | Fabio Gobbo | (Ulivo-Ind.) |
| | Riccardo Franco Levi | (Ulivo-M) |
| Minister for the Interior | Giuliano Amato | (Ulivo-Ind.) |
| Minister for Justice | Clemente Mastella | (UDEUR) |
| Minister for Economic Affairs and Finance | Tommaso Padoa Schioppa | (Ind.) |
| Minister for Economic Development | Pierluigi Bersani | (Ulivo-DS) |
| Minister for Universities and Reseach | Fabio Mussi | (Ulivo-DS) |
| Minister for Education | Beppe Fioroni | (Ulivo-M) |
| Minister for Labour and Social Security | Cesare Damiano | (Ulivo-DS) |
| Minister for Social Solidarity | Paolo Ferrero | (PRC) |
| Minister for Defence | Arturo Parisi | (Ulivo-M) |
| Minister for Agriculture, Food and Forestry | Paolo De Castro | (Ulivo-Ind.) |
| Minister for the Environment and Territorial Protection | Alfonso Pecoraro Scanio | (FV) |
| Minister for Infrastructure | Antonio Di Pietro | (IDV) |
| Minister for Transport | Alessandro Bianchi | (PdCI) |
| Minister for Health | Livia Turco | (Ulivo-DS) |
| Minister for Communications | Paolo Gentiloni | (Ulivo-M) |
| Minister for Regional Affairs and Local Autonomy | Linda Lanzillotta | (Ulivo-M) |
| Minister in charge of carrying out the Government’s programme | Giulio Santagata | (Ulivo-M) |
| Minister for Institutional Reform | Luigi Nicolais | (Ulivo-DS) |
| Minister for Civil Rights and Equal Opportunities | Barbara Pollastrini | (Ulivo-DS) |
| Minister for European Policy and International Trade | Emma Bonino | (RnP) |
| Minister for Relations with Parliament and Institutional Reform | Vannino Chiti | (Ulivo-DS) |
| Minister for Family Policy | Rosy Bindi | (Ulivo-M) |
| Minister for Youth and Sports | Giovanna Melandri | (Ulivo-DS) |